Dr. Matthew R. Gronquist

Dr. GronquistDr. Matthew R. Gronquist
Associate Professor of Chemistry
331 Science Center
State University of New York at Fredonia
Fredonia, NY 14063
Tel: (716) 673-4842
Fax: (716) 673-3347



Biologically derived small molecules play a central role in many ecological interactions. Our research efforts are aimed at the detection, characterization, and chemical manipulation of such biogenic chemicals as they pertain to predator-prey interactions among arthropods. Recent examples involve novel molecules isolated from spiders and fireflies.

Gronquist Research


Chemical structures identified from a) the defensive secretion of the firefly Lucidota atra and b) venom from the Brown Recluse spider ( Loxosceles reclusa )



  1. “Defensive and chemical characterization of the froth produced by the cercopid Aphrophora cribrata”  del Campo, M. L., King, J. T., Gronquist, M. R.  Chemoecology 2011, 21, 1.


  1. “Arthropod Natural Products”  Gronquist, M. R., Schroeder, F. C. In Comprehensive Natural Products II ;  Mander, L.; Liu, H. W., Eds.; Elsevier:  Oxford, 2010; volume 2, 67.


  1. “NMR-Spectroscopic Screening of Spider Venom Reveals Sulfated Nucleosides as Major Components for the Brown Recluse and Related Species”  Schroeder, F. C., Taggi, A. E., Gronquist, M., Malik, R. U., Grant, J. B., Eisner, T. Meinwald, J.  Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 14283.  Covered in The Telegraph UK, September 16, 2008.


  1. “Effects of AiiA-Mediated Quorum Quenching in Sinorhizobium meliloti on Quorum-Sensing Signals, Proteome Patterns, and Symbiotic Interactions”  Gao, M., Chen, H., Eberhard, A., Gronquist, M. R., Robinson, J. B., Connolly, M.,  Teplitski, M., Rolfe, B. G., Bauer, W. D.  Mol. Plant-Microbe Interact2007, 20, 843.


  1. “Extending the Scope of NMR Spectroscopy with Microcoil Probes”  Schroeder, F. C.,  Gronquist, M. R.  Angew. Chem. Int. Ed.  2006, 45, 7122.


  1. “Shunning the Night to Elude the Hunter: Diurnal Fireflies and the Femmes Fatales”  Gronquist, M. R., Schroeder, F. C., Ghiradella, H., Hill, D., McCoy, E. M., Meinwald, J. M., Eisner, T.  Chemoecology 2006, 16, 39.


  1. “Chromosome and plasmid-encoded N-acyl homoserine lactones produced by Agrobacterium vitis wildtype and mutants that differ in their interactions with grape and tobacco”  Li, Y., Gronquist, M. R., Hao, G., Holden, M. R., Eberhard, A., Scott, R. A., Savka, M. A., Szegedi, E., Sule, S., Burr, T. J.  Physiol. Molec. Plant. Pathol.  2006, 67, 284.


  1. “sinI- and expR-Dependent Quorum Sensing in Sinorhizobium meliloti”  Gao, M., Chen, H., Eberhard, A., Gronquist, M. R., Robinson, J. B., Rolfe, B. G., Bauer, W. D.  J. Bact. 2005, 187, 7931.


  1. “Exploring Uncharted Terrain in Nature’s Structure Space Using Capillary NMR Spectroscopy: 13 Steroids from 50 Fireflies.” Gronquist, M. R., Meinwald, J., Eisner, T., Schroeder, F. C. J. Am. Chem. Soc. 2005, 127, 10810.  Covered in Chem. & Eng. News 2005, 83(33), 38., and in Chemistry World 2005, 2(7).


  1.  “Quorum sensing in halophilic bacteria: detection of N-acyl-homoserine lactones in the exopolysaccharide-producing species of Halomonas”  Llamas, I.,  Quesada, E., Martı´ nez-Ca´ novas, M. J., Gronquist, M., Eberhard, A., Gonza´ lez, J. E.  Extremophiles 2005, 9, 333.


  1. “Direct Binding of the Quorum Sensing Regulator CepR of Burkholderia cenocepacia to Two Target Promoters in vitro.”  Weingart, C. L., White, C. E., Liu, S., Chai, Y., Cho, H., Tsai, C., Wei, Y., Delay, N. R., Gronquist, M. R., Eberhard, A., Winans, S. C. Mol. Microbiol. 2005, 57(2), 452.


  1. “Nutritional Requirements of Allisonella histaminiformans, a Ruminal Bacterium that Decarboxylates Histidine and Produces Histamine.”  Garner, M. R., Gronquist, M. R., Russel, J. B.  Curr. Microbiol2004, 49(4), 295.


  1. “Chemical Identification of N-acyl Homoserine Lactone Quorum Sensing Signals Produced by Sinorhizobium meliloti Strains in Defined Medium.”  Teplitski, M., Eberhard, A., Gronquist, M. R., Gao, M., Robinson, J. B., Rolfe, B. G., Bauer, W. D.  Arch. Microbiol. 2003, 180(6), 494.


  1. “Characterization of the Sinorhizobium meliloti sinR/sinI  Locus and the Production of Novel N-acyl Homoserine Lactones.”  Marketon, M. M., Gronquist, M. R., Eberhard, A., Gonzalez, J. E.  J. Bact. 2002, 184, 5686.


  1. “Attractive and Defensive Functions of the Ultraviolet Pigments of a Flower (Hypericum calycinum).”  Gronquist, M. R., Bezzerides, A., Attygalle, A., Meinwald, J., Eisner, M., Eisner, T.  Proc. Natl. Acad. Sci. U.S.A., 2001, 98, 13745.  Covered in Chem. & Eng. News 2001, 79(48), 10., Covered in Science News 2001, 160(23), 367., and Natural History Magazine, March 2002.


  1. “Synthesis of Unsaturated Polyazamacrolides from the Ladybird Beetle Subcoccinella vigintiquatuorpunctata.”  Gronquist, M. R., Meinwald, J. J. Org. Chem. 2001, 66, 1075.


Chemistry and Biochemistry Department Office

221 Science Center
State University of New York at Fredonia
Fredonia, NY 14063
(716) 673-3281